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Changing the local environment of reactants

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  • What is the role of activation energy in enzyme activity?

  • Activation energy is needed to break down chemical bonds allowing the reaction to occur. When an enzyme binds to a substrate, it lowers the substrate molecules鈥?energy to react to form products. This increases the chance of the reaction occurring and therefore increases the rate of reaction.

  • How do enzymes lower the energy needed for a chemical reaction?

  • By manipulating the substrates of the reaction, the enzyme can lower the necessary energy needed to make the reaction occur. The enzyme itself is not a component of the chemical reaction and is the same molecule at the beginning of the reaction as it is at the end.

  • What is the role of binding energy in enzyme-substrate reactions?

  • Binding energy is the primary energy source used by the enzyme to lower the activation energy. So the key aspect of the enzyme-substrate reaction is that the enzyme reduces the activation energy for this reaction, thereby augmenting the rate. The binding energy provides this.

  • How does an enzyme act to lower Ea?

  • An enzyme can act in several ways to lower Ea. It does this by forming an enzyme-substrate (ES) complex. 1. The enzyme may hold the substrates in such a way as to distort the substrate bonds closer to their form in the transition state.

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